Date of Publication :7th August 2025

Abstract: As CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology becomes increasingly decentralised, current biosecurity measures, largely bi- ological and isolated, fail to match the pace and com- plexity of emerging threats. This study introduces a pi- oneering bio-digital framework that reimagines CRISPR containment through the lens of cryptographic security. Bridging synthetic biology and cybersecurity, we map genetic safeguards such as kill-switches, auxotrophy, and sequence-based controls to digital security counterparts such as timeout protocols, access tokens, and digital sig- natures. This conceptual convergence informs a novel “lock-and-key” architecture that integrates molecular- level genetic locks with blockchain-enabled access poli- cies and zero-trust governance models. Unlike exist- ing frameworks, our approach enables programmable, tamper-resistant access control over gene editing func- tionalities, potentially transforming CRISPR biosecu- rity from reactive regulation to proactive, design-driven containment. This work not only addresses a critical gap in hybridised containment strategies but also lays the foundation for globally standardised, cryptographi- cally enforced biosecurity in an age of DIY gene editing.

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