Date of Publication :21st August 2017
Abstract: Glucose monitoring technology has been used for three decades in diabetes management. Current instruments use enzymatic methods to measure concentration of glucose and provide information on the point samples. Continuous glucose monitoring devices have become more recently available offering more detailed information on glucose excursions. The continuous glucose sensor may become a critical component of the closed loop insulin delivery system in future applications, and as such it must be sensitive, fast, reliable and appropriate for continuous use by patients. Blood glucose control is a valuable tool in diabetes management. A series of appropriate glucose biosensors have been developed since it is recommended to maintain normal blood glucose levels. The development of glucose biosensors including point-of-care applications, continuous glucose monitoring systems and non-invasive glucose monitoring systems has been significantly enhanced over the last 50 years. Nevertheless, the achievement of accurate and reliable glucose monitoring continues to pose many challenges. It needs more technical improvements in glucose biosensors, standardization of the analytical objectives for their efficiency, and continuous assessment and training of lay users. This article discusses the brief history, basic principles, analytical success and current status in clinical practice of glucose biosensors.
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